Related Experiment Video
Updated: Jul 5, 2026

Live Imaging of the Ependymal Cilia in the Lateral Ventricles of the Mouse Brain
Published on: June 1, 2015
Ependymal cyst in a cynomolgus macaque (Macaca fascicularis)
Ingrid L Bergin1, Brandy Campbell, Dalen W Agnew
1Diagnostic Center for Population and Animal Health, Michigan State University Lansing, MI 48910, USA. Bergin@dcpah.msu.edu
Background:
A focal hypointense intracranial lesion was detected by magnetic resonance imaging in the right caudal occipital lobe of the cerebrum in an asymptomatic cynomolgus macaque (Macaca fascicularis).
Results:
Following euthanasia, gross evaluation of the lesion revealed a 1 cm diameter, wedge-shaped intracranial cavitation without apparent communication with the ventricles. Histologically, the lesion was lined by ciliated cuboidal to low columnar epithelium that showed immunopositivity for cytokeratin, S-100, and GFAP.
Conclusion:
Based upon the gross, histologic, and immunohistochemical findings, this lesion was classified as an ependymal cyst. In the human patients, ependymal cysts are benign, non-infectious, non-inflammatory lesions of the central nervous system that are believed to originate from aberrant migration of ependymal cells during development. To our knowledge, this is the first report of an ependymal cyst in a non-rodent veterinary species and the first report of a benign intracranial cyst of any classification in a non-human primate.
More Related Videos
Related Concept Videos
Cerebral Edema l: Introduction
Brain Abscess l: Introduction
Cryptococcal Meningitis

