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Updated: Jul 5, 2026
Rapid Detection of Fecal Antigen of Helicobacter pylori Infection Based on Double Antibody Sandwich Detection Technology
Published on: May 23, 2025
Helicobacter pylori infection does not accelerate the age-related progression of arteriosclerosis: a 4-year follow-up
Chie Honda1, Kyoichi Adachi, Noriyuki Arima
1Second Department of Internal Medicine, Shimane University School of Medicine, Izumo, Japan.
Insights
Helicobacter pylori (H. pylori) infection did not accelerate arteriosclerosis progression in Japanese individuals over four years. Age-related changes in blood pressure and pulse wave velocity occurred similarly in both infected and uninfected groups.
Area of Science:
- Cardiovascular Health
- Infectious Diseases
- Gerontology
Background:
- Helicobacter pylori (H. pylori) infection is linked to cardiovascular diseases.
- The specific impact of H. pylori on arteriosclerosis progression remains under-researched.
Purpose of the Study:
- To investigate the role of H. pylori infection in the development and progression of arteriosclerosis.
- To compare arteriosclerosis parameters in H. pylori-seropositive versus seronegative individuals over time.
Main Methods:
- 258 individuals were monitored for arteriosclerosis parameters (SBP, ABI, PWV) over 4 years.
- H. pylori infection status was determined via serum antibody testing.
- Changes in arteriosclerotic parameters were compared between H. pylori-seropositive and seronegative groups.
Main Results:
- No significant differences in arteriosclerosis parameters were observed between H. pylori-seropositive and seronegative groups at baseline or after 4 years.
- Both groups showed age-related increases in systolic blood pressure (SBP) and pulse wave velocity (PWV).
- H. pylori-seropositive individuals had lower high-density lipoprotein cholesterol levels.
Conclusions:
- H. pylori infection does not accelerate age-related arteriosclerosis progression in the studied Japanese population.
- The findings suggest H. pylori's role in cardiovascular disease may not be directly linked to arteriosclerosis acceleration.
Background And Aim:
Helicobacter pylori (H. pylori) infection has been reported to correlate with the onset of cardiovascular diseases. However, the relationship between H. pylori infection and the progression of arteriosclerosis has not been fully investigated. The aim of this study was to clarify the possible role of H. pylori infection in the development of arteriosclerosis.
Methods:
Study subjects were 258 cases who attended their annual medical check-ups and were twice investigated by the parameters of arteriosclerosis at a 4-year interval. Arteriosclerotic parameters (systolic blood pressure [SBP]), ankle brachial index [ABI], and pulse wave velocity [PWV]) were measured non-invasively using an automatic device. H. pylori-infection status was determined by assaying serum anti-H. pylori IgG antibodies. The changes in the arteriosclerotic parameters during the 4 years were compared between H. pylori-seropositive and seronegative individuals.
Results:
A total of 166 subjects (64.3%) were H. pylori-seropositive. After adjustment for gender, age, body mass index, and smoking and drinking habits, there were no differences in any of the arteriosclerotic parameters between the groups, not only at enrollment but after the 4 years, although the high-density lipoprotein cholesterol levels of the seropositive groups were significantly lower than those of seronegative groups. SBP and PWVs were significantly increased during 4 years in both the seropositive and seronegative groups. The percentage of changes in SBP and PWVs, which were calculated by ([values after 4 years--values at enrollment/values at enrollment] x 100), did not differ between the groups.
Conclusion:
H. pylori infection does not accelerate the age-related progression of arteriosclerosis in Japanese individuals.
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