Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding
Hsin-Ju Hsieh1, Christina G S Palmer, Sinead Harney
1Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA. hjhsieh@gene.com
Abstract:
Non-inherited maternal antigens encoded by specific HLA-DRB1 alleles (NIMA) have been implicated as a rheumatoid arthritis (RA) risk factor. Using genotype data from North American Rheumatoid Arthritis Consortium study participants and the maternal-fetal genotype incompatibility (MFG) test, we find evidence for offspring allelic effects but no evidence for NIMA as a RA risk factor. We discuss possible reasons why our result conflicts with several previous studies (including one of our own) that used RA patients from northern Europe.
Related Concept Videos
Rh Blood Group
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Blood Types
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Blood Typing
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...

