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Updated: Jul 5, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
A mixture model approach to multiple testing for the genetic analysis of gene expression
Cyril Dalmasso1, Joseph Pickrell, Marianne Tuefferd
1JE 2492 Universite Paris-Sud, Hôpital Paul Brousse - Batiment 15/16, 16 Avenue Paul Vaillant Couturier, Villejuif CEDEX 94807, France. dalmasso@vjf.inserm.fr
Abstract:
With the availability of very dense genome-wide maps of markers, multiple testing has become a major difficulty for genetic studies. In this context, the false-discovery rate (FDR) and related criteria are widely used. Here, we propose a finite mixture model to estimate the local FDR (lFDR), the FDR, and the false non-discovery rate (FNR) in variance-component linkage analysis. Our parametric approach allows empirical estimation of an appropriate null distribution. The contribution of our model to estimation of FDR and related criteria is illustrated on the microarray expression profiles data set provided by the Genetic Analysis Workshop 15 Problem 1.
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