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Updated: Jul 5, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Comparing strategies for evaluation of candidate genes in case-control studies using family data
Xin Tian1, Jungnam Joo, Colin O Wu
1Office of Biostatistics Research, National Heart, Lung and Blood Institute, 6701 Rockledge Drive, Bethesda, Maryland 20892, USA. tianx@nhlbi.nih.gov
Abstract:
The goal of this analysis is to compare different test strategies for genetic association in case-control studies using related individuals. The first test is the trend test that is corrected for related individuals on the basis of identity-by-descent information. The second approach is to use generalized estimating equations to adjust for the correlation between relatives, and the third is the multiple outputation method. We compare the power of these test strategies in a simulation study, and apply these methods to a candidate gene dataset of Genetic Analysis Workshop 15 from the North American Rheumatoid Arthritis Consortium.
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