Linkage, case-control association, and family-based association tests for complex disorders
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Updated: Jul 5, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Brian K Suarez1,2, Robert Culverhouse3, Carol H Jin1
1Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, St. Louis, Missouri 63110, USA.
Abstract:
We carried out an analysis of the Genetic Analysis Workshop 15 simulated Problem 3 data. We restricted ourselves to the present/absent phenotype. Linkage analysis revealed a very strong signal on chromosome 6. Association analysis revealed additional susceptible loci located on chromosomes 11 and 18. The latter two signals were subsequently verified with linkage analysis - but only after 20 replicates were pooled. Analysis of linkage disequilibrium patterns, in concert with family-based association tests, led us to infer the presence of a second chromosome 6 locus located in the vicinity of single-nucleotide polymorphisms 160-162. These analyses were carried out without knowledge of the model used to generate the simulation.
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