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Power of the 2-locus TDT for testing the interaction of two susceptibility genes
Salma Kotti1, Mathieu Bourgey, Françoise Clerget-Darpoux
1Université Paris-Sud, UMR-S535, 94817 Villejuif, France. kotti@vjf.inserm.fr
BMC Proceedings
|May 10, 2008
Abstract:
We recently proposed a new strategy: 2-locus TDT for detecting two susceptibility genes through their interaction in trio families. We apply our method to two candidate genes, A and C, on the Genetic Analysis Workshop 15 (GAW15) simulated rheumatoid arthritis data and study the power to identify an interactive effect of these genes.This study was performed with full knowledge of the answers.
