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Updated: Jul 5, 2026

Establishment of Deep Hypothermic Circulatory Arrest in Rats
Published on: December 16, 2022
Hypothermia and cardiac arrest: the promise of intra-arrest cooling
Roger A Band1, Benjamin S Abella
1Department of Emergency Medicine, University of Pennsylvania, 3400 Spruce Street, Ground Ravdin, Philadelphia PA 19104, USA.
Abstract:
Over the past several years, the implementation of therapeutic hypothermia has provided an exciting opportunity toward improving survival from out-of-hospital cardiac arrest. There are compelling data to support the prompt use of therapeutic hypothermia for initial survivors from out-of-hospital cardiac arrest, but animal data have suggested that initiation of therapeutic hypothermia during the intra-arrest period may significantly improve outcomes even further. In the first feasibility study in humans, Bruel and colleagues report on the implementation of this intra-arrest approach among patients suffering out-of-hospital cardiac arrest, an exciting prospect that is discussed in the present commentary.
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