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Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Published on: May 18, 2016

Loiasis: African eye worm.

Jeannie J Padgett¹, Kathryn H Jacobsen

¹Department of Global & Community Health, College of Health and Human Services, George Mason University, 4400 University Drive 5B7, Fairfax, VA 22030, USA.

Transactions of the Royal Society of Tropical Medicine and Hygiene

|May 10, 2008

Summary

This summary is machine-generated.

Loiasis, caused by the Loa loa parasite transmitted by flies, affects West and Central Africa. Mass drug treatments for other diseases raise concerns about severe side effects in co-endemic areas.

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Area of Science:

Parasitology
Tropical Medicine
Public Health

Background:

Loa loa is a filarial parasite transmitted by Chrysops flies.
Loiasis is endemic in West and Central African rainforests, with cases also seen in travelers.
Infected individuals may be asymptomatic or show microfilariae in blood or adult worms under the skin/sclera.

Purpose of the Study:

To highlight the endemic nature of Loiasis.
To discuss the potential risks associated with mass drug administration programs.
To address concerns regarding ivermectin use in co-endemic regions.

Main Methods:

Literature review on Loa loa transmission and Loiasis.
Analysis of clinical presentations of Loiasis.
Review of mass treatment program guidelines and safety data.

Main Results:

Loiasis is prevalent in specific African regions and among mobile populations.
Asymptomatic infections are common, complicating disease surveillance.
Ivermectin use in co-endemic areas poses a risk of severe adverse events.

Conclusions:

Loiasis remains a significant public health concern in endemic areas.
Careful consideration of co-endemicity is crucial for mass drug administration strategies.
Further research is needed to ensure safe and effective treatment protocols.