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Related Concept Videos

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

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Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

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Related Experiment Videos

Multitargeted cancer prevention by quercetin.

Akira Murakami¹, Hitoshi Ashida, Junji Terao

¹Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

|May 10, 2008

Summary

Quercetin, a plant flavonoid, shows antioxidant and anti-cancer properties. Dietary intake of quercetin may help prevent chemically induced cancers, particularly in the colon and lung.

Area of Science:

Nutritional biochemistry
Molecular biology
Cancer prevention research

Background:

Quercetin is a widely distributed plant flavonoid with potent antioxidant and free radical-scavenging properties.
Its biological activity is influenced by its glycoside form and metabolic conversion to conjugates in the body.
Active quercetin aglycone can be regenerated from conjugates, especially during inflammation.

Purpose of the Study:

To investigate the molecular targets and pathways through which quercetin exerts its cancer prevention effects.
To review evidence on the role of quercetin in preventing chemically induced carcinogenesis and its association with lung cancer prevention.

Main Methods:

Review of scientific literature on quercetin's antioxidant activity, metabolism, and interactions with molecular targets.

Related Experiment Videos

Analysis of rodent studies on dietary quercetin and chemically induced carcinogenesis.

Examination of epidemiological studies on dietary quercetin intake and cancer incidence.

Main Results:

Quercetin aglycone interacts with the aryl hydrocarbon receptor, a key player in chemically induced cancers.
Quercetin modulates critical signaling pathways like MEK/ERK and Nrf2/Keap1, involved in inflammation and carcinogenesis.
Rodent studies show quercetin prevents colon cancer; epidemiological studies suggest a link to reduced lung cancer risk.

Conclusions:

Dietary quercetin demonstrates significant potential as a cancer preventive agent.
Further research is warranted to fully elucidate quercetin's mechanisms and optimize its use in cancer prevention strategies.