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Updated: Jul 5, 2026

Visualizing the DNA Damage Response in Purkinje Cells Using Cerebellar Organotypic Cultures
Published on: December 27, 2024
Defective responses to DNA single- and double-strand breaks in spinocerebellar ataxia
Martin F Lavin1, Nuri Gueven, Padraic Grattan-Smith
1Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia. martin.lavin@qimr.edu.au
Abstract:
Failure to maintain the integrity of DNA/chromatin can result in genome instability and an increased risk of cancer. The description of a number of human genetic disorders characterised not only by cancer predisposition but by a broader phenotype including neurodegeneration suggests that maintaining genome stability is also important for preserving post-mitotic neurons. The identification of genes associated with other neurodegenerative disorders provides further evidence for the importance of DNA damage response and DNA repair genes in protecting against neurodegeneration. This theme is further developed in this review.
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