Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Plant-derived mitochondria mitigate aging-related neurodegeneration by reprogramming microglial mitochondrial energy metabolism.

Translational neurodegeneration·2026

Same author

Foxs1-mediated transformation of CD34<sup>+</sup> fibroblast to myCAFs promotes tumor growth.

EMBO molecular medicine·2026

Same author

[Impact of effective health information acquisition on hemophilia-related health literacy among caregivers of underage hemophilia patients].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026

Same author

CD34<sup>+</sup> cell-derived endothelial cells orchestrate vascular and immune remodeling in the transplanted liver.

Journal of hepatology·2026

Same author

Multiple pathways of CD34<sup>+</sup> cell differentiation during embryogenesis.

Cell death and differentiation·2026

Same author

Assessing conformation validity and rationality of deep learning-generated 3D molecules.

Nature communications·2026

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

Stem cells and transplant arteriosclerosis.

¹Cardiovascular Division, King's College London, 125 Coldharbour Ln, London SE5 9NU, United Kingdom. qingbo.xu@kcl.ac.uk

Circulation Research

|May 10, 2008

Summary

This summary is machine-generated.

Stem cells play a role in transplant arteriosclerosis, potentially repairing damaged vessels or contributing to lesion formation. Research explores their homing, differentiation, and controversial contributions to transplant vascular disease.

More Related Videos

Immunomagnetic Isolation of the Vascular Wall-Resident CD34+ Stem Cells from Mice

Immunomagnetic Isolation of the Vascular Wall-Resident CD34⁺ Stem Cells from Mice

Published on: December 22, 2023

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Published on: June 20, 2025

Related Experiment Videos

Last Updated: Jul 5, 2026

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

Immunomagnetic Isolation of the Vascular Wall-Resident CD34+ Stem Cells from Mice

Immunomagnetic Isolation of the Vascular Wall-Resident CD34⁺ Stem Cells from Mice

Published on: December 22, 2023

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Published on: June 20, 2025

Area of Science:

Immunology
Regenerative Medicine
Vascular Biology

Background:

Transplant arteriosclerosis is a major cause of organ transplant failure.
The precise role of stem cells in its pathogenesis is not fully understood.
Stem cells' ability to differentiate and repair tissues suggests involvement in vascular remodeling.

Purpose of the Study:

To review current research on stem cell involvement in transplant arteriosclerosis.
To discuss mechanisms of stem cell homing and differentiation in allografts.
To highlight controversial aspects of stem cell contributions to transplant vascular disease.

Main Methods:

Literature review of recent studies on stem cells and transplant arteriosclerosis.
Analysis of proposed mechanisms for stem cell homing and differentiation.
Identification and discussion of controversial findings in the field.

Main Results:

Stem cells, including recipient-derived and progenitor cells, may repair damaged endothelium and replenish vascular cells.
Stem/progenitor cells may accumulate in the intima and differentiate into smooth muscle cells.
Controversies exist regarding bone marrow-derived stem cells differentiating into smooth muscle cells in neointimal lesions.

Conclusions:

Stem cells are implicated in transplant arteriosclerosis through repair and potentially pathological remodeling.
Understanding stem cell mechanisms is crucial for addressing transplant vascular disease.
Further research is needed to resolve controversies surrounding stem cell differentiation in allografts.