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The association between plasma adiponectin level and hypertension
Anoop Shankar1, Steve Marshall, Jialiang Li
1Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ashankar@nus.edu.sg
Acta Cardiologica
|May 13, 2008
Summary
Lower adiponectin levels are linked to hypertension in both men and women. This association persists even after accounting for other cardiovascular risk factors, highlighting adiponectin
Area of Science:
- Endocrinology
- Cardiovascular Health
- Metabolic Syndrome Research
Background:
- Low plasma adiponectin is associated with dyslipidemia and metabolic syndrome.
- The independent relationship between adiponectin and hypertension remains unclear.
- Previous studies on adiponectin and hypertension focused solely on men.
Purpose of the Study:
- To investigate the independent relationship between plasma adiponectin levels and hypertension.
- To analyze this association separately in men and women.
Main Methods:
- Cross-sectional study of 664 participants (mean age 52.5 years, 50.3% men).
- Hypertension defined as systolic BP ≥ 140 mmHg, diastolic BP ≥ 90 mmHg, or self-reported diagnosis with medication.
- Controlled for key confounding factors in multivariable analyses.
Main Results:
- Lower plasma adiponectin levels were significantly associated with hypertension (OR 3.40, 95% CI 2.04-5.68).
- This positive association was consistent across gender-specific analyses (men P-trend < 0.0001; women P-trend = 0.01).
Conclusions:
- Plasma adiponectin is independently associated with hypertension in both men and women.
- This relationship is not explained by traditional cardiovascular risk factors like dyslipidemia or renal function.
- Findings clarify the role of adiponectin in hypertension.
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