Human papillomavirus infection in patients with residual or recurrent cervical intraepithelial neoplasia
Related Experiment Video
Updated: Jul 5, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
1University Department of Gynecology and Perinatology Maribor University Hospital, Maribor, Slovenia. iztok.takac@sb-mb.si
Aims And Background:
The main purpose of this longitudinal study was to evaluate the frequency of HPV infection in patients with residual or recurrent CIN.
Methods:
797 consecutive patients with CIN, treated with conization, were included. In 38 patients with residual or recurrent CIN in whom reconization was performed, infection with high-risk HPV types was analyzed.
Results:
Reconization was performed in 4.8% of patients. Before reconization, 21 patients (55.3%) were infected with high-risk HPV and 17 patients (44.7%) were HPV negative. Among the HPV-negative patients, two (11.8%) had CIN 1, five (29.4%) CIN 2, nine (52.9%) CIN 3 and one patient (5.9%) had microinvasive cancer of the uterine cervix. The difference in frequency of infection with high-risk HPV was not significant (chi-square 0.372; P > 0.05).
Conclusions:
On the basis of the study results it is not possible to recommend the HPV test as the only method of detection of residual or recurrent CIN after conization.
Related Concept Videos
Genital Herpes
Mechanisms of Retrovirus-induced Cancers
Sexually Transmitted Infections
Herpes
Chickenpox
Cytomegalovirus Disease
