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Related Concept Videos

Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
Factors Influencing Drug Absorption: Drug Dissolution01:27

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The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...

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Related Experiment Video

Updated: Jul 5, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Tablet formulation studies on an oxcarbazepine-beta cyclodextrin binary system.

N V Patel1, N P Chotai, M P Patel

  • 1Anand Pharmacy College, Anand, Gujarat, India. Nirav2564@yahoo.co.in

Die Pharmazie
|May 13, 2008
PubMed
Summary
This summary is machine-generated.

Developing oxcarbazepine-beta-cyclodextrin (OX-beta-CD) binary systems significantly improved the dissolution of this poorly soluble anti-epileptic drug. Kneaded OX-beta-CD systems in tablet formulations demonstrated superior drug release and stability.

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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Published on: August 15, 2016

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Physical Pharmacy

Background:

  • Oxcarbazepine is a BCS Class II anti-epileptic drug with poor water solubility, where dissolution is the rate-limiting factor for absorption.
  • Beta-cyclodextrin (beta-CD) is a commonly used excipient for enhancing the solubility and dissolution of poorly water-soluble drugs.

Purpose of the Study:

  • To develop and evaluate tablet formulations of oxcarbazepine-beta-cyclodextrin (OX-beta-CD) binary systems to improve drug dissolution.
  • To compare the dissolution properties of different binary system preparation methods and tablet manufacturing techniques.

Main Methods:

  • Phase solubility studies were conducted to determine the complexation between oxcarbazepine and beta-CD.
  • Three types of binary systems were prepared: physical mixtures, kneaded systems, and coevaporated systems at a 1:1 molar ratio.
  • Tablet formulations were prepared using wet granulation and direct compression methods.
  • Dissolution testing and accelerated stability studies were performed.

Main Results:

  • Phase solubility studies confirmed a 1:1 molar complexation of oxcarbazepine with beta-CD.
  • The kneaded system (OX-beta-CD KS) exhibited superior dissolution, with 100.10% drug release in 15 minutes, outperforming other binary systems and pure oxcarbazepine.
  • Tablet formulations containing OX-beta-CD binary systems, particularly those prepared by kneading and direct compression, showed significantly improved dissolution profiles compared to pure drug formulations.
  • Stability studies indicated no significant changes in drug release or content in stored samples.

Conclusions:

  • Oxcarbazepine-beta-cyclodextrin binary systems, especially kneaded systems, are effective in enhancing the dissolution properties of poorly soluble oxcarbazepine.
  • Tablet formulations incorporating these binary systems offer a viable approach for improving the bioavailability of oxcarbazepine.
  • Direct compression method yielded superior dissolution properties compared to wet granulation for these tablet formulations.