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Updated: Jul 5, 2026

Chemical Triphosphorylation of Oligonucleotides
Published on: June 2, 2022
Poly ADP-ribose polymerase-1: an international molecule of mystery
Bethany C Woodhouse1, Grigory L Dianov
1Medical Research Council Radiation Oncology & Biology Unit, University of Oxford, Oxford OX3 7DQ, UK.
Abstract:
Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the most abundant proteins within mammalian cells. First described more than 45 years ago, PARP-1 has been the subject of many studies and was shown to be involved in multiple aspects of cellular metabolism. Despite many interesting studies that implicate PARP-1 in transcription, chromatin remodelling, apoptosis, DNA repair and several neurological disorders, its precise role is still unclear. This review will discuss the role of PARP-1 in DNA repair and propose a model whereby PARP-1 operates as a modulator of base excision repair capacity.
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