Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Bioactivation and Tissue Toxicity01:25

Bioactivation and Tissue Toxicity

Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Food to Function: Cross-Kingdom Transfer and Regulatory Potential of Dietary microRNAs Highlighted by Breast Milk.

Annual review of nutrition·2026
Same author

Organization and functioning of the Italian Departments of Mental Health in the pandemic and post-pandemic period.

Annali dell'Istituto superiore di sanita·2025
Same author

Psycho-Socio-Behavioural Substrates of Non-Cancer Chronic Pain: A Twin Study in Italian Adults.

Journal of pain research·2025
Same author

Chronic Pain Prevalence and Psychosocial Burden in the Italian Population from the 2019 European Health Interview Survey.

International journal of environmental research and public health·2025
Same author

Unveiling the Chemical Safety of Clothing Articles, Textiles and Footwear With Regard to the Presence of Carcinogenic, Mutagenic, or Reprotoxic Substances, Endocrine Disruptors and Skin Sensitizers Under EU Regulatory Restrictions.

Contact dermatitis·2025
Same author

Distribution of different classes of CSF3R mutations and co-mutational pattern in 360 myeloid neoplasia.

Annals of hematology·2025

Related Experiment Video

Updated: Jul 5, 2026

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

The ISS Carcinogens Data Bank (BDC).

Roberto Binetti1, Federica Ceccarelli, Francesca Marina Costamagna

  • 1Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy.

Annali Dell'Istituto Superiore Di Sanita
|May 13, 2008
PubMed
Summary

The Data Bank on Carcinogens (BDC) provides accessible carcinogenicity data from global agencies to aid risk management. This resource supports administrators and industry professionals in understanding cancer-causing agent classifications.

More Related Videos

The Lambda Select cII Mutation Detection System
07:08

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Related Experiment Videos

Last Updated: Jul 5, 2026

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

The Lambda Select cII Mutation Detection System
07:08

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
05:19

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Area of Science:

  • Toxicology
  • Environmental Health
  • Risk Assessment

Background:

  • Carcinogen identification and classification are crucial for public health and regulatory decisions.
  • Existing resources for carcinogen data can be fragmented and difficult to access.
  • The Istituto Superiore di Sanità developed a centralized data bank to address these challenges.

Purpose of the Study:

  • To present the Data Bank on Carcinogens (BDC) as a centralized, factual resource.
  • To support risk management decision-making for administrators and industry professionals.
  • To provide concise carcinogenicity evaluations from major international organizations.

Main Methods:

  • Compilation of carcinogenicity evaluations from the European Union, IARC, USEPA, NTP, and CCTN.
  • Presentation of data in a concise format with bibliographic references.
  • Inclusion of direct links to original sources and relevant websites where available.

Main Results:

  • The BDC offers a consolidated overview of carcinogen classifications.
  • Classifications are qualitative, based on the criteria of each originating institution.
  • The data bank facilitates access to original research and detailed evaluations.

Conclusions:

  • The BDC serves as a valuable, user-friendly tool for experts, researchers, and risk managers.
  • It enhances informed decision-making regarding carcinogenic agents.
  • The data bank promotes better understanding and management of carcinogen risks.