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Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then passed on to...
Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle01:19

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and refractory oxide ion...
Atomic Emission Spectroscopy: Lab01:29

Atomic Emission Spectroscopy: Lab

AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...
Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation01:26

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy  (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used.
Matrix-Assisted Laser Desorption Ionization (MALDI)01:08

Matrix-Assisted Laser Desorption Ionization (MALDI)

Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and characterization of various biomolecules, including proteins, peptides, nucleic acids, and carbohydrates. MALDI is an ionization technique, widely employed in biological and medical research, as well as in fields like pharmacology and biochemistry.The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix...

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Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS)
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A new laser ablation system for quantitative analysis of solid samples with ICP-MS.

Tomoharu Ishida1, Takanori Akiyoshi, Akiko Sakashita

  • 1Analysis & Characterization Research Dept., Steel Research Laboratory, JFE Steel Corporation, Chiba, Japan. tom-ishida@jfe-steel.co.jp

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
|May 13, 2008
PubMed
Summary

A new laser ablation system coupled with inductively coupled plasma mass spectrometry (LA-ICP-MS) offers high-sensitivity metal analysis. This advanced LA-ICP-MS technique provides accurate and precise quantitative results for metal materials.

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Spectroscopy

Background:

  • Laser ablation (LA) is a recognized method for quantitative analysis.
  • Inductively coupled plasma mass spectrometry (ICP-MS) is a powerful analytical technique.
  • Existing LA systems may have limitations in sensitivity and precision for metal analysis.

Purpose of the Study:

  • To develop a novel laser ablation system for high-sensitivity quantitative analysis of metal materials.
  • To integrate the new LA system with ICP-MS for enhanced analytical performance.
  • To evaluate the accuracy, precision, and detection limits of the developed LA-ICP-MS system.

Main Methods:

  • Development of a new LA system featuring a high-frequency Q-switched laser and scanning mirrors.
  • Utilizing repetitive irradiation patterns to mitigate elemental fractionation.
  • Coupling the LA system with ICP-MS for elemental analysis.
  • Validation using NIST steel standard reference materials (SRMs).

Main Results:

  • The developed LA system, operating at 0.6 W average laser power, produced stable signals comparable to solution-based ICP-MS.
  • Analytical performance in terms of accuracy and precision was comparable to conventional solution ICP-MS.
  • High correlation coefficients (over 0.99) were observed between elemental content and intensity ratios to Fe.
  • The system demonstrated good precision for iron sample analysis, with relative standard deviations (RSD) indicating capability for ultra-trace analysis (ppm levels with 20-30 ppb standard deviation).
  • Detection limits were found to be in the order of 10 ppb for most elements.

Conclusions:

  • The newly developed LA-ICP-MS system is effective for high-sensitivity quantitative analysis of metal materials.
  • The system achieves accuracy and precision comparable to conventional solution ICP-MS.
  • It is capable of analyzing trace and ultra-trace elemental concentrations in iron samples with excellent precision and low detection limits.