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Published on: August 4, 2023
Assessing antibiotic therapy for Acinetobacter baumannii infections in an academic medical center
D G Dauner1, J R May, J C H Steele
1Department of Pharmacy, Medical College of Georgia Health Inc., Augusta, GA, USA. ddauner@slhduluth.com
Abstract:
In 2006, our clinical microbiology laboratory suspected that our institution was experiencing an increase in Acinetobacter baumannii infections and was concerned about resistance. A cross-sectional study was conducted to determine the A. baumannii antibiogram for 2006 and assess the appropriateness of antibiotics therapy. The study included all adult inpatients with a positive culture for A. baumannii between January 1 2006 and December 31 2006. A total of 129 isolates were identified. A. baumannii was highly susceptible to imipenem (97.7%) and meropenem (95.3%). Among the aminoglycosides, A. baumannii had reduced susceptibility to gentamicin (40.5%). Based on their susceptibility patterns, only 76 (58.9%) antibiotics regimens were susceptible against the isolates. At our institution, A. baumannii remains highly susceptible to the carbapenems and aminoglycosides. We encourage our practitioners to analyze the susceptibility pattern of each isolate when ordering antibiotics, which will help increase our rate of appropriate antibiotic selection.
Insights
Acinetobacter baumannii infections are increasing, but remain susceptible to carbapenems and aminoglycosides. Analyzing antibiotic susceptibility patterns improves appropriate treatment selection for Acinetobacter baumannii.
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Clinical microbiology laboratories observed a rise in Acinetobacter baumannii infections in 2006.
- Concerns arose regarding the increasing antimicrobial resistance of Acinetobacter baumannii.
Purpose of the Study:
- Determine the 2006 antibiogram of Acinetobacter baumannii at the institution.
- Assess the appropriateness of antibiotic therapy for Acinetobacter baumannii infections.
Main Methods:
- A cross-sectional study was conducted.
- Included adult inpatients with positive Acinetobacter baumannii cultures from January 1 to December 31, 2006.
- Analyzed 129 Acinetobacter baumannii isolates.
Main Results:
- Acinetobacter baumannii showed high susceptibility to imipenem (97.7%) and meropenem (95.3%).
- Reduced susceptibility was noted for gentamicin (40.5%).
- Only 58.9% of antibiotic regimens were susceptible to the isolates based on susceptibility patterns.
Conclusions:
- Acinetobacter baumannii remains highly susceptible to carbapenems and aminoglycosides at the institution.
- Practitioners should analyze isolate susceptibility patterns for appropriate antibiotic selection.
- This analysis can improve the rate of appropriate antibiotic selection for Acinetobacter baumannii infections.
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