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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

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Related Experiment Video

Updated: Jul 5, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Giant cell hepatitis in adults.

L Gábor1, K Pál, S Zsuzsa

  • 11st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Ullöi út 26, 1085, Budapest, Hungary.

Pathology Oncology Research : POR
|May 13, 2008
PubMed
Summary

Giant cell hepatitis, rare in adults, often presents with cholestasis and progresses to cirrhosis. This study details two adult cases, suggesting Hepatitis C virus and autoimmune disease as potential causes.

Area of Science:

  • Hepatology
  • Immunology
  • Virology

Background:

  • Giant cell hepatitis is a liver reaction to injury, common in children but rare in adults.
  • It frequently involves cholestasis and can rapidly progress to cirrhosis.
  • Etiologies include autoimmune, metabolic, toxic, or viral factors, though sometimes remain unidentified.

Purpose of the Study:

  • To report two cases of giant cell hepatitis in adult patients.
  • To explore potential etiologies in adult giant cell hepatitis.

Main Methods:

  • Case report analysis of two adult patients diagnosed with giant cell hepatitis.
  • Review of clinical history, laboratory results, and etiological investigations.

Main Results:

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  • Case 1: Suspected Hepatitis C virus infection as the cause.
  • Case 2: Suspected autoimmune disease as the cause.

Conclusions:

  • Giant cell hepatitis can occur in adults with diverse underlying causes.
  • Hepatitis C virus infection and autoimmune diseases are potential, though uncommon, etiologies in adult giant cell hepatitis.