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Updated: Jul 5, 2026
09:54
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
Three cases of HIV-1 seroreversion
Pathology Oncology Research : POR
|May 13, 2008
Summary
Transient HIV seropositivity can occur in hemophiliacs due to factor VIII concentrate exposure and in EBV patients from immune responses. These rare cases highlight the importance of careful interpretation of HIV antibody tests.
Area of Science:
- Immunology
- Virology
- Hematology
Background:
- Human Immunodeficiency Virus (HIV) antibody testing is crucial for diagnosis.
- Transient seropositivity can complicate accurate HIV diagnosis.
- Understanding causes of false-positive HIV tests is important for clinical practice.
Purpose of the Study:
- To investigate and report rare cases of transient human immunodeficiency virus (HIV) seropositivity.
- To explore potential causes of transient HIV seropositivity in specific patient populations.
Main Methods:
- Serial serum sample analysis using multiple HIV antibody enzyme immunoassays (EIA).
- Confirmatory testing including immunofluorescence assay and Western blot (WB).
- Additional molecular and enzymatic assays (PCR, reverse transcriptase) in one case.
Main Results:
- Two hemophiliac patients showed transient reactivity in HIV screening and confirmatory assays, possibly linked to factor VIII concentrate exposure.
- One patient with acute Epstein-Barr Virus (EBV) infection exhibited transient HIV seropositivity.
- Western blot remained indeterminate in one case after 2.5 years, while EIA tests became negative.
Conclusions:
- Transient HIV seropositivity can be observed in hemophiliacs and EBV-infected individuals.
- Factor VIII concentrate may induce temporary immune responses leading to false-positive HIV tests.
- EBV infection can trigger polyclonal B-cell activation, potentially causing cross-reactive antibody production.
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