Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiasthma Drugs: Muscarinic Receptor Antagonists01:20

Antiasthma Drugs: Muscarinic Receptor Antagonists

Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction01:22

Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction

The radical dimerization of ketones or aldehydes gives vicinal diols through a pinacol coupling reaction. However, the behavior of titanium metals used for the reaction as a source of electrons is unusual. When the reaction is carried out in the presence of titanium, diols can be isolated at low temperatures. Else titanium further reacts with diols, forming alkenes through the McMurry reaction.
Antiasthma Drugs: Methylxanthines01:24

Antiasthma Drugs: Methylxanthines

Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Per- and polyfluoroalkyl substances in the atmospheric total suspended particles in Karachi, Pakistan: Profiles, potential sources, and daily intake estimates.

Chemosphere·2021
Same author

Synthesis of (4R)-thiazolidine carboxylic acid and evaluation of antioxidant potential.

Pakistan journal of pharmaceutical sciences·2020
Same author

Combination Therapy of Clinically Approved Antifungal Drugs Is Enhanced by Conjugation with Silver Nanoparticles.

International microbiology : the official journal of the Spanish Society for Microbiology·2019
Same author

In-vitro evaluation and in-silico studies applied on newly synthesized amide derivatives of N-phthaloylglycine as Butyrylcholinesterase (BChE) inhibitors.

Computational biology and chemistry·2018
Same author

Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides: A systematic approach from in vitro, in silico to in vivo studies.

Bioorganic & medicinal chemistry·2017
Same author

Novel fluorene-based supramolecular sensor for selective detection of amoxicillin in water and blood.

Ecotoxicology and environmental safety·2017

Related Experiment Video

Updated: Jul 5, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
09:56

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

Published on: November 18, 2015

Two new coumarins from Murraya paniculata.

Sumayya Saied1, Shaikh Sirajuddin Nizami, Itrat Anis

  • 1Department of Chemistry, University of Karachi, Karachi, Pakistan. chem_ref@yahoo.com

Journal of Asian Natural Products Research
|May 13, 2008
PubMed
Summary
This summary is machine-generated.

Researchers isolated two new coumarins, murrmeranzin and murralonginal, from Murraya paniculata. One compound, minumicrolin, demonstrated mild butyrylcholinesterase inhibition activity.

Related Experiment Videos

Last Updated: Jul 5, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
09:56

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example

Published on: November 18, 2015

Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacology

Background:

  • Murraya paniculata is a plant species known for its diverse secondary metabolites.
  • Coumarins are a class of organic compounds with various biological activities.
  • Identifying novel compounds from medicinal plants is crucial for drug discovery.

Purpose of the Study:

  • To isolate and characterize chemical constituents from the aerial parts of Murraya paniculata.
  • To evaluate the isolated compounds for potential biological activities, specifically butyrylcholinesterase inhibition.

Main Methods:

  • Phytochemical investigation involving extraction and isolation techniques.
  • Structure elucidation of isolated compounds using comprehensive spectral analysis (e.g., NMR, MS).
  • In vitro assay to determine butyrylcholinesterase inhibition activity.

Main Results:

  • Two new coumarins, murrmeranzin (1) and murralonginal (2), were identified.
  • Four known coumarins, minumicrolin (3), murrangatin (4), meranzin hydrate (5), and hainanmurpanin (6), were also isolated.
  • Minumicrolin (3) exhibited mild inhibitory activity against butyrylcholinesterase.

Conclusions:

  • The aerial parts of Murraya paniculata are a rich source of coumarin derivatives.
  • The isolation of novel coumarins contributes to the chemotaxonomic understanding of the genus Murraya.
  • Minumicrolin shows potential as a lead compound for developing butyrylcholinesterase inhibitors.