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Related Experiment Video

Updated: Jul 5, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

Serotonin: a review.

L F Mohammad-Zadeh¹, L Moses, S M Gwaltney-Brant

¹Southern Arizona Veterinary Specialty and Emergency Center, Tucson, AZ 85705, USA. ladan@mohammad-zadeh.com

Journal of Veterinary Pharmacology and Therapeutics

|May 13, 2008

Summary

This summary is machine-generated.

Serotonin, a neurotransmitter, impacts various bodily functions and is linked to mood disorders. New research explores serotonin toxicity, known as Serotonin Syndrome, in both humans and animals.

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Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome

Published on: September 23, 2015

Area of Science:

Neuroscience
Pharmacology
Veterinary Medicine

Background:

5-Hydroxytryptamine (serotonin) is a key neurotransmitter.
Serotonin influences gastrointestinal motility, vascular tone, platelet function, and mood.
Research in animal models has elucidated serotonin's roles in human physiology and disease pathophysiology.

Purpose of the Study:

To review the physiology of serotonin.
To explore serotonin's role in various pathophysiologic mechanisms.
To discuss the clinical presentation and implications of Serotonin Syndrome.

Main Methods:

Literature review of studies on serotonin's physiological roles.
Analysis of research involving animal models to understand serotonin's functions.
Examination of clinical data and case studies related to serotonin toxicity.

Main Results:

Serotonin modulates critical physiological functions, including gastrointestinal and vascular tone.
Dysregulation of serotonin is implicated in mood disorders, emesis, migraine, IBS, and hypertension.
Increased use of serotonergic drugs has led to the identification of Serotonin Syndrome as a novel toxicity in humans and animals.

Conclusions:

Understanding serotonin's complex roles is crucial for both human and veterinary medicine.
Serotonin Syndrome represents a significant adverse effect of serotonergic system manipulation.
Further research is needed to fully elucidate the mechanisms and management of serotonin toxicity.