Related Experiment Video

Updated: Jul 5, 2026

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

Nephrotoxicity in the setting of invasive fungal diseases

Andrew J Ullmann1

  • 1Klinikum der Johannes-Gutenberg-Universität, Mainz, Germany. ullmann@uni-mainz.de

Mycoses
|May 28, 2008
PubMed

Insights

Amphotericin B, a broad-spectrum antifungal, frequently causes kidney damage (nephrotoxicity). This nephrotoxicity is linked to higher mortality and longer hospital stays in patients with invasive fungal diseases.

Area of Science:

  • Mycology
  • Nephrology
  • Pharmacology

Background:

  • Amphotericin B is a critical antifungal medication.
  • Nephrotoxicity is a significant adverse effect associated with Amphotericin B treatment.
  • The incidence and impact of Amphotericin B-induced nephrotoxicity require careful consideration in clinical practice.

Purpose of the Study:

  • To review definitions of nephrotoxicity in the context of patient outcomes.
  • To analyze the impact of nephrotoxicity on patients with invasive fungal diseases.
  • To highlight the consequences of Amphotericin B-associated kidney damage.

Main Methods:

  • Literature review of studies defining and reporting on amphotericin B nephrotoxicity.
  • Analysis of patient outcomes, including mortality and hospital length of stay.
  • Synthesis of findings related to different nephrotoxicity definitions.

Main Results:

  • Nephrotoxicity is a common complication in patients treated with Amphotericin B.
  • Patients experiencing nephrotoxicity often exhibit increased mortality rates.
  • Prolonged mean hospital length of stay is associated with Amphotericin B-induced nephrotoxicity.

Conclusions:

  • The definition of nephrotoxicity impacts outcome assessment in patients with invasive fungal diseases.
  • Amphotericin B-associated nephrotoxicity adversely affects patient outcomes.
  • Exploring less nephrotoxic antifungal alternatives may improve treatment results and reduce patient morbidity.

More Related Videos

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...