Association between arterial stiffness and peritoneal small solute transport rate

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Xing-wei Zhe1, Xin-kui Tian, Wei Chen

  • 1Division of Nephrology, Peking University Third Hospital, Beijing, China.

Artificial Organs
|May 13, 2008
PubMed

Insights

High peritoneal transport in continuous ambulatory peritoneal dialysis (CAPD) is linked to increased aortic stiffness. This study found that the D/P(cr) ratio, a measure of solute transport, independently predicts aortic stiffness in CAPD patients.

Area of Science:

  • Nephrology and Cardiovascular Medicine
  • Dialysis Patient Outcomes
  • Vascular Physiology

Background:

  • Cardiovascular disease causes 40-50% of mortality in dialysis patients.
  • High peritoneal transport in continuous ambulatory peritoneal dialysis (CAPD) predicts patient outcomes.
  • Aortic stiffness is an established cardiovascular risk factor.

Purpose of the Study:

  • To investigate the potential link between peritoneal small solute transport and aortic stiffness in CAPD patients.
  • To explore aortic stiffness using pulse wave velocity (PWV) measurements.

Main Methods:

  • Seventy-six CAPD patients were assessed for aortic stiffness via brachial pulse pressure (PP) and carotid-femoral PWV.
  • Peritoneal small solute transport was measured by D/P(cr) at 4 hours.
  • Bioimpedance analysis was used to determine the extracellular water to total body water (E/T) ratio; C-reactive protein was also measured.

Main Results:

  • Carotid-femoral PWV positively correlated with age, time on PD, diabetes, D/P(cr), PP, and E/T ratio.
  • Multivariate regression identified E/T ratio, PP, age, and D/P(cr) as independent predictors of carotid-femoral PWV.
  • The D/P(cr) ratio was an independent predictor of elevated carotid-femoral PWV.

Conclusions:

  • Increased peritoneal small solute transport rate (indicated by D/P(cr)) is linked to higher aortic stiffness in CAPD patients.
  • Aortic stiffness in CAPD patients is independently predicted by the E/T ratio, PP, age, and D/P(cr).
  • Findings suggest a connection between increased aortic stiffness and elevated peritoneal small solute transport.

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