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Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
Published on: November 7, 2020
Controversies in liver transplantation for hepatitis C
Sandeep Mukherjee1, Michael F Sorrell
1Section of Gastroenterology and Hepatology, Nebraska Medical Center, Omaha, Nebraska 68198-3285, USA. smukherj@unmc.edu
Gastroenterology
|May 13, 2008
Summary
Recurrent Hepatitis C after liver transplantation is common, leading to cirrhosis and retransplantation. Current treatments are often ineffective and have side effects, highlighting the need for better management strategies.
Area of Science:
- Hepatology
- Transplantation Medicine
- Immunology
Background:
- Hepatitis C is a leading cause of liver transplantation in the US.
- Recurrent Hepatitis C post-transplant is nearly universal in viremic patients.
- Recurrent Hepatitis C can cause cirrhosis and necessitate retransplantation.
Purpose of the Study:
- To review controversial topics in recurrent Hepatitis C after liver transplantation.
- To highlight uncertainties in the natural history of post-transplant Hepatitis C.
- To discuss management strategies and their impact in the postoperative setting.
Main Methods:
- Literature review focusing on controversial aspects of recurrent Hepatitis C.
- Analysis of factors influencing disease progression and management.
- Discussion of clinical observations in the postoperative setting.
Main Results:
- Antiviral therapy for recurrent Hepatitis C is frequently ineffective and has side effects.
- Pre- and perioperative factors influencing outcomes are often beyond clinician control.
- Postoperative management, including immunosuppression and antiviral therapy, allows for intervention assessment.
Conclusions:
- Significant uncertainties remain regarding Hepatitis C recurrence post-liver transplant.
- Effective treatment strategies for recurrent Hepatitis C are lacking.
- Further research is needed to improve outcomes for transplant recipients with Hepatitis C.
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