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Updated: Feb 6, 2026
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Protein Modifications: Protein Kinases and Phosphatases
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Live donors in liver transplantation
1Center for Liver Diseases and Transplantation, Columbia College of Physicians and Surgeons, New York, New York 10032, USA. rb464@columbia.edu
Gastroenterology
|May 13, 2008
Summary
Living donor liver transplantation (LDLT) offers survival benefits but faces challenges due to donor risks and limited adoption. Further research is needed to define optimal use and increase acceptance.
Area of Science:
- Transplantation Medicine
- Surgical Innovation
- Organ Donation
Background:
- Living donor liver transplantation (LDLT) emerged to address deceased donor organ shortages.
- Initial enthusiasm waned due to donor risks and highly publicized deaths.
- Despite improvements, LDLT remains underutilized in adult liver transplantation.
Purpose of the Study:
- To review the current status and challenges of living donor liver transplantation.
- To highlight the established survival benefits of LDLT.
- To identify factors hindering broader LDLT adoption.
Main Methods:
- Analysis of historical trends in LDLT procedures.
- Review of outcomes data, including the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL).
- Examination of donor risks and ethical considerations.
Main Results:
- LDLT demonstrates a survival benefit for recipients.
- Significant donor risks (morbidity, mortality) persist.
- LDLT constitutes less than 5% of adult liver transplants, unlike kidney transplantation.
Conclusions:
- LDLT has proven efficacy but requires further definition of optimal donor and recipient criteria.
- Broader acceptance and experience are crucial for LDLT growth.
- Addressing ethical concerns and the learning curve impact is essential for future development.
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