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Related Experiment Video

Updated: Jul 5, 2026

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease

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Published on: October 20, 2023

Barriers in the brain: a renaissance?

Norman R Saunders¹, C Joakim Ek, Mark D Habgood

¹Department of Pharmacology, University of Melbourne, Parkville, VIC 3010, Australia. n.saunders@unimelb.edu.au

Trends in Neurosciences

|May 13, 2008

Summary

Brain barrier mechanisms control molecule exchange, crucial for brain health. Dysfunctional barriers impact neurological diseases and drug delivery, but new research offers potential solutions.

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Area of Science:

Neuroscience
Biochemistry
Pharmacology

Background:

Brain barrier mechanisms are vital for regulating molecular exchange between the central nervous system and the body.
Proper functioning is essential for normal brain activity, maintenance, and development.
Dysfunction is implicated in neurological disorders and hinders therapeutic agent delivery.

Purpose of the Study:

To summarize current understanding of brain barrier mechanisms.
To highlight the challenges posed by dysfunctional barriers in neurological diseases and drug delivery.
To explore novel approaches for understanding and circumventing these barriers.

Main Methods:

Review of existing literature on brain barrier physiology and pathology.
Analysis of recent research on developing and dysfunctional brain barriers.
Exploration of emerging strategies for therapeutic agent delivery.

Main Results:

Brain barriers are critical but poorly understood in vivo.
Barrier dysfunction contributes to various neurological conditions.
Novel research directions are emerging to address these challenges.

Conclusions:

Further research into brain barrier mechanisms is essential.
New therapeutic strategies may overcome existing delivery obstacles.
Understanding these barriers is key for treating neurological diseases.