Related Experiment Video
Updated: Jul 5, 2026
09:39
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Non-hyaluronic acid fillers
1St. Louis University, Paris, France. drdaphnetb@free.fr
Clinics in Dermatology
|May 13, 2008
Summary
Dermal fillers offer varied durations for treating facial wrinkles, from temporary to permanent options. Understanding filler types is crucial for effective facial volume restoration and managing potential side effects.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Biomaterials
Background:
- Facial wrinkles and volume loss are common aesthetic concerns.
- Numerous dermal fillers are available, with varying durations of effect.
- Newer fillers can stimulate collagen production for volume restoration.
Purpose of the Study:
- To review the characteristics and clinical applications of various dermal fillers.
- To discuss the duration of effects and potential adverse events associated with different filler types.
- To emphasize the importance of dermasurgeon knowledge for patient satisfaction.
Main Methods:
- Review of current literature on dermal fillers.
- Classification of fillers based on biodegradability and duration.
- Analysis of reported efficacy and adverse events.
Main Results:
- Fillers range from biodegradable (months) to permanent implants.
- Semi-permanent fillers (e.g., polylactic acid, ceramics) offer longer duration but risk granulomas.
- Permanent fillers have historically higher risks, but newer formulations show decreased adverse events.
Conclusions:
- Dermasurgeons must understand filler indications, duration, and risks.
- Selection of appropriate fillers is key to managing patient expectations and outcomes.
- Advancements in filler technology aim to improve safety and efficacy profiles.
Related Concept Videos
01:23Glycosaminoglycans
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
01:17Connective Tissue Fibers and Ground Substance
One of the significant functions of connective tissue is connecting tissues and organs. Unlike epithelial tissue that is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. The matrix usually includes a large amount of extracellular material produced by the connective tissue cells that are embedded within it. It plays a significant role in the functioning of this tissue. The major component of the matrix is a...
01:30Local Anesthetics: Chemistry and Structure-Activity Relationship
Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
01:05Proteoglycans
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
01:29Additives and Fillers in Concrete
Additives and fillers are integral to enhancing the properties of concrete. Pozzolans and blast-furnace slag are additives or admixtures due to their reactions with calcium hydroxide released during cement hydration. Fillers, which are finely ground and similar in fineness to Portland cement, improve concrete attributes such as workability density, and reduce capillary bleeding or cracking. Some fillers possess hydraulic properties or participate in benign reactions within the cement paste.
The...
The...