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Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: Jul 5, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
07:03

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides

Published on: January 31, 2014

Combating photoaging with percutaneous collagen induction.

Desmond Fernandes1, Massimo Signorini

  • 1The Renaissance Surgical Clinic and Department of Plastic Reconstructive Surgery, University of Cape Town, Cape Town 8001, South Africa. des@drdes.co.za

Clinics in Dermatology
|May 13, 2008
PubMed
Summary
This summary is machine-generated.

Percutaneous collagen induction therapy is a safe and effective anti-aging treatment that improves skin appearance by stimulating collagen production. This method also minimizes scars, offering a lasting solution for youthful skin.

Related Experiment Videos

Last Updated: Jul 5, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
07:03

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides

Published on: January 31, 2014

Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Regenerative Medicine

Background:

  • Patients seek treatments to restore a youthful appearance, with skin quality being a key factor.
  • Aging skin often exhibits reduced thickness and elasticity, impacting perceived youthfulness.
  • Existing surgical options like facelifts address structural changes but not skin quality directly.

Purpose of the Study:

  • To evaluate percutaneous collagen induction as an anti-aging skin treatment.
  • To assess the efficacy of percutaneous collagen induction in improving scar appearance.
  • To explore the benefits of combining percutaneous collagen induction with scientific skincare.

Main Methods:

  • Percutaneous collagen induction therapy involves controlled skin micro-injury to stimulate natural healing processes.
  • The technique aims to induce collagen remodeling, replacing scar tissue with normal collagen.
  • Treatment is applied to improve skin texture, reduce wrinkles, and minimize acne and burn scars.

Main Results:

  • Percutaneous collagen induction effectively enhances skin appearance, promoting thicker and tighter skin.
  • The therapy successfully minimizes acne and burn scars by remodeling scar collagen.
  • The procedure offers an alternative to ablative treatments, preserving the epidermis and allowing for repeat applications.

Conclusions:

  • Percutaneous collagen induction is a valuable therapeutic option for anti-aging and scar revision.
  • The method provides an inside-out and surface-level approach to skin rejuvenation.
  • Its safety profile and versatility make it suitable for various skin concerns and anatomical areas.