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Postmastectomy locoregional recurrence and distant metastasis in breast carcinoma patients

Emin Yildirim1, Ugur Berberoglu

  • 1Department of Surgery, Ankara Oncology Training and Research Hospital, Konutkent-2, A-4 Blok 44, Ankara 06530, Turkey. yildirimemin@yahoo.com

Breast (Edinburgh, Scotland)
|May 13, 2008
PubMed

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...