An HIV-infected patient with fever, pancytopenia, and renal failure: is this end-stage AIDS?
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Updated: Jul 5, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
Anibal Maldonado1, Richard L Oehler
1Division of Infectious Disease and International Medicine, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida, USA.
Abstract:
Histoplasmosis is a fungal infection caused by Histoplasma capsulatum. Although immunocompetent persons with H. capsulatum infections are usually asymptomatic, several clinical syndromes can manifest in immunocompromised patients. We report a case of a 61-year-old man with advanced HIV infection who presented with weight loss, anorexia, and renal failure. His symptoms were initially attributed to end-stage AIDS, but a more specific diagnosis was pursued. Bone marrow biopsy resulted in the discovery of disseminated histoplasmosis. This case illustrates the importance of actively pursuing the diagnosis of an opportunistic infection in persons with end-stage AIDS, treating the opportunistic infection aggressively, and maximizing the effectiveness of antiretroviral therapy.
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