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Updated: Jul 5, 2026
09:24
Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model
Published on: February 11, 2021
Leukocyte migration in experimental inflammatory bowel disease
E P Van Rees1, M J Palmen, F R Van De Goot
1Department of Cell Biology and Immunology Faculty of Medicine Vrije Universiteit Van der Boechorststraat 7 Amsterdam 1081 BT The Netherlands.
Mediators of Inflammation
|January 1, 1997
Summary
Leukocyte adhesion molecules mediate transendothelial migration, crucial for inflammatory bowel disease pathogenesis. Targeting these molecules offers potential therapeutic strategies to reduce tissue damage.
Area of Science:
- Immunology
- Gastroenterology
Background:
- Leukocyte transendothelial migration is a multistep process involving adhesion molecules like selectins, chemokines, and integrins.
- This migration is critical for the influx of neutrophils, monocytes, and lymphocytes into inflamed tissues.
- The process plays a significant role in the pathogenesis of chronic inflammatory bowel disease (IBD).
Purpose of the Study:
- To discuss the importance of different adhesion molecule groups in chronic inflammatory bowel disease.
- To explore the role of leukocyte extravasation in IBD pathogenesis.
- To consider therapeutic strategies targeting leukocyte migration to prevent tissue damage.
Main Methods:
- Review and discussion of existing literature on adhesion molecules and leukocyte migration in IBD.
- Analysis of the roles of selectins, chemokines, and integrins in the context of chronic inflammation.
- Evaluation of potential therapeutic interventions targeting leukocyte extravasation.
Main Results:
- Adhesion molecules are essential mediators of leukocyte extravasation into inflamed tissues.
- Specific adhesion molecule pathways are implicated in the pathogenesis of chronic inflammatory bowel disease.
- The multistep nature of transendothelial migration offers multiple targets for therapeutic intervention.
Conclusions:
- Understanding the molecular mechanisms of leukocyte migration is vital for IBD research.
- Targeting adhesion molecules and their interactions presents a promising therapeutic avenue for managing chronic inflammatory bowel disease.
- Inhibiting leukocyte extravasation could mitigate tissue damage in IBD.
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