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Chryseobacterium meningosepticum infection: antibiotic susceptibility and risk factors for mortality

Po-Pin Hung1, Yu-Hui Lin, Chin-Fu Lin

  • 1Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|May 14, 2008
PubMed
Abstract

Insights

Hypoalbuminemia, increased pulse rate, and central venous line infections are risk factors for poor outcomes in Chryseobacterium meningosepticum infections. Antibiotic choice did not significantly impact patient survival in this study.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Critical Care Medicine

Background:

  • Limited antibiotic options exist for Chryseobacterium meningosepticum infections.
  • The role of C. meningosepticum in neonates and immunocompromised patients is recognized, but clinical data are scarce.
  • This study addresses the limited clinical data on C. meningosepticum infections.

Purpose of the Study:

  • To investigate risk factors for mortality in patients with C. meningosepticum infections.
  • To determine the antibiotic susceptibility profiles of clinical C. meningosepticum isolates.
  • To identify prognostic indicators for C. meningosepticum infections.

Main Methods:

  • Retrospective analysis of patient data, including demographics, clinical parameters, and treatment.
  • Statistical analysis using Fisher's exact test to identify prognostic parameters.
  • Antimicrobial susceptibility testing of 19 isolates against seven antibiotics, reporting MIC values.

Main Results:

  • Hypoalbuminemia, elevated pulse rate, and central venous line presence were associated with poor outcomes (p<0.05).
  • Appropriate antibiotic use did not show a significant association with clinical outcomes (p=0.21).
  • Levofloxacin demonstrated lower MIC values (MIC50/90: 0.12/2 µg/mL) compared to ciprofloxacin (MIC50/90: 0.5/4 µg/mL).

Conclusions:

  • Hypoalbuminemia, increased pulse rate, and central venous line infections are significant predictors of poor outcomes.
  • These findings highlight key clinical factors associated with mortality in C. meningosepticum infections.
  • Antibiotic susceptibility data provide insights into treatment options, with levofloxacin showing promising activity.

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