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Updated: Jul 5, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

A prospective study of antimicrobial-related adverse drug reactions in hospitalized patients

Hsin-Yun Sun1, Yee-Chun Chen, Yi-Wen Wang

  • 1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|May 14, 2008
PubMed
Abstract

Insights

Adverse drug reactions (ADRs) to antimicrobials are common in Taiwanese hospitalized patients, affecting 24.1%. A history of drug allergy and longer hospital stays increase the risk of these reactions.

Area of Science:

  • Pharmacovigilance
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • No prior systematic evaluation of antimicrobial-related adverse drug reactions (ADRs) in Taiwanese patients.
  • Antimicrobial-ADRs pose a significant challenge in hospitalized populations.

Purpose of the Study:

  • To assess the incidence and risk factors of antimicrobial-related ADRs.
  • To identify clinical manifestations and causative agents of these ADRs in hospitalized patients.

Main Methods:

  • Prospective enrollment of 299 patients receiving antimicrobial treatment for at least two days.
  • Analysis of data from patients experiencing parenteral antimicrobial-related ADRs.

Main Results:

  • The overall incidence of antimicrobial-related ADRs was 24.1% (93.1% Type B).
  • Increased risk associated with prior drug allergy history and longer hospitalization duration.
  • Carbapenems, amphotericin B, and glycopeptides showed high ADR incidence; common manifestations included blood dyscrasias, dermatomucosal effects, and febrile reactions.

Conclusions:

  • Antimicrobial-related ADRs are frequent among hospitalized patients in Taiwan.
  • Understanding risk factors and common ADRs is crucial for patient safety.

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