Related Experiment Video
Updated: Jul 5, 2026
10:01
Quantification of Fungal Colonization, Sporogenesis, and Production of Mycotoxins Using Kernel Bioassays
Published on: April 23, 2012
[Corneofungimetry: A bioassay for dermato-mycology.]
J E Arrese Estrada1, G Piérard
1Servicio de Dermatopatología, Universidad de Liège, Bélgica. J.Arrese@ulg.ac.be.
Revista Iberoamericana De Micologia
|May 14, 2008
Summary
Corneofungimetry is a novel bioassay for evaluating antifungal drug efficacy. This method classifies topical and oral antifungals based on their activity and toxicity within the stratum corneum.
Area of Science:
- Dermatomycology
- Pharmacology
- Bioassay development
Context:
- Assessing antifungal drug effectiveness is crucial for treating superficial fungal infections.
- Existing methods may not fully replicate the in vivo environment of the stratum corneum.
- There is a need for standardized assays to compare antifungal agents.
Purpose:
- To introduce and describe corneofungimetry, a bioassay for evaluating antifungal drug effects.
- To demonstrate the utility of corneofungimetry in classifying topical and oral antifungals.
- To establish a method for assessing drug potency at the stratum corneum level.
Summary:
- Corneofungimetry utilizes human stratum corneum, obtained via cyanoacrylate skin surface strippings, for fungal culture.
- The assay allows for the determination of the antifungal spectrum of activity and fungitoxicity.
- It provides a means to evaluate the potency of both topical and oral antifungal medications within the stratum corneum.
Impact:
- Corneofungimetry offers a standardized approach to antifungal drug assessment.
- This bioassay can guide the selection of appropriate antifungal therapies.
- It contributes to a better understanding of drug penetration and efficacy in dermatological conditions.
