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[Description of 165 episodes of fungemia: A multicenter study.]

M Sota1, C Ezpeleta, R Cisterna

  • 1Servicio de Microbiología, Hospital de Basurto, Bilbao, Spain.

Revista Iberoamericana De Micologia
|May 14, 2008
PubMed
Abstract

Insights

This study analyzed 165 fungemia episodes from 34 Spanish hospitals, finding most cases were nosocomial and predominantly caused by Candida albicans. Mortality reached 33.3%.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Epidemiology

Context:

  • Fungal infections (fungemia) pose a significant threat in hospital settings.
  • Understanding the epidemiology of fungemia is crucial for effective treatment and prevention strategies.
  • This study leverages data from the Multicenter Study Sepsis Data across 34 Spanish hospitals.

Purpose:

  • To describe the key features of fungemia cases identified within a large multicenter study.
  • To analyze the demographics, origins, causative fungi, and treatment of fungemia episodes.
  • To report the overall mortality rate associated with fungemia.

Summary:

  • A total of 165 fungemia episodes were analyzed, with a majority (72.1%) being nosocomial.
  • Candida albicans was the most frequently isolated fungus (44.2%).
  • Commonly affected patient areas included medical (38.8%) and intensive care units (29.1%).
  • Neoplasia (26.1%) and HIV infection (16.9%) were prevalent underlying conditions.
  • Fluconazole (54.4%) and amphotericin B (41.9%) were the primary antifungal agents used.
  • The overall mortality rate for fungemia was 33.3%.

Impact:

  • Provides valuable epidemiological data on fungemia in Spain, aiding clinical decision-making.
  • Highlights the significant burden of nosocomial fungemia and identifies key risk factors.
  • Informs antifungal stewardship and infection control practices in healthcare settings.

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