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Related Experiment Video

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Generation and Coherent Control of Pulsed Quantum Frequency Combs

Generation and Coherent Control of Pulsed Quantum Frequency Combs

Published on: June 8, 2018

BK channel modulators: a comprehensive overview.

Antonio Nardi¹, Søren-Peter Olesen

¹Department of Medicinal Chemistry, NeuroSearch A/S, Pederstrupvej 93, 2750 Ballerup, Denmark. ant@neurosearch.dk

Current Medicinal Chemistry

|May 14, 2008

Summary

This summary is machine-generated.

Despite strong evidence, no large calcium-activated potassium (BK) channel modulators are approved. This review classifies BK channel modulators to aid drug discovery for this promising target.

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Area of Science:

Pharmacology
Medicinal Chemistry
Molecular Biology

Background:

Large calcium-activated potassium (BK) channels are implicated in numerous pathophysiological conditions.
Despite extensive research, BK channels remain an underexplored drug target with no approved modulators.
Previous clinical trials for BK channel openers have been discontinued.

Purpose of the Study:

To provide a comprehensive overview and classification of BK channel modulators.
To aid medicinal chemists in understanding the chemical space of BK channel modulators.
To highlight structure-activity relationships for BK channel modulating agents.

Main Methods:

Classification of BK channel modulators based on origin and chemical structure.
Review of endogenous, naturally-occurring, and synthetic modulators (inhibitors and openers).
Analysis of marketed and investigational drugs with BK-modulating properties.

Main Results:

BK channel modulators are categorized into six distinct groups.
The review details chemical structures and origins of various BK channel modulators.
Structure-activity relationships are discussed where data is available.

Conclusions:

BK channels represent a promising yet challenging drug target.
A systematic classification of BK channel modulators is crucial for future drug development.
Continued research into novel chemical entities is essential for advancing BK channel-targeted therapies.