Synthesis and biological evaluation of N-phosphoryl dipeptide derivatives as potent apoptosis inducers
Xiaoqing Yu1, Chunyan Tan, Nan Zhang
1The Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen, P.R. China, 518055.
Protein and Peptide Letters
|May 14, 2008
Abstract:
A series of N-phosphoryl dipeptide derivatives with trimethoxyaniline moiety were synthesized, in which compound 2a DIPP-Val-Phe-Ar exhibited the best inhibitory activity against K562 cells with the IC(50) at 9.7 microM. Its antitumor effects are due to the induction of apoptosis which was further confirmed by morphological study and flow cytometry analysis.
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