Related Experiment Video
Updated: Jul 5, 2026

Organic Solvent-Based Protein Precipitation for Robust Proteome Purification Ahead of Mass Spectrometry
Published on: February 7, 2022
Effect of cosolvents on the stabilization of bioactive peptides from bovine milk alpha-casein
Sistla Srinivas1, Vishweshwaraiah Prakash
1Department of Protein Chemistry and Technology, Central Food Technological Research Institute, Mysore-570020, India.
Abstract:
Peptides with more than one biological activity are many a times multifunctional peptides. Two peptides with multifunctional properties from alpha (S2)-casein were stabilized in presence of cosolvents for their biological activities like ACE inhibition activity and antioxidant activity. These bioactive peptides in cosolvents were also thermostable. Infra red spectra of peptides in cosolvents reveal no change in the secondary structure in presence of cosolvents. Correlation between sequence, structure and composition of peptides on biological activities were studied.
Related Concept Videos
Solvating Effects
Leveling Effect
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Colloids
The Colloidal State
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
