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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: Jul 5, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Immunotherapy of HCC.

Tim F Greten1, Michael P Manns, Firouzeh Korangy

  • 1Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Germany, Carl Neuberg Str. 1, 30625 Hannover, Germany. greten.tim@mh-hannover.de

Reviews on Recent Clinical Trials
|May 14, 2008
PubMed
Summary
This summary is machine-generated.

Hepatocellular carcinoma (HCC) treatment is limited. Immunotherapy shows promise as a safe and effective systemic option for HCC, with ongoing trials evaluating its efficacy in patients.

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Area of Science:

  • Hepatology and Oncology
  • Cancer Immunotherapy

Background:

  • Hepatocellular carcinoma (HCC) is a prevalent cancer globally, with rising rates in Western countries.
  • Effective treatments for HCC are limited, primarily to surgical and local ablative therapies.
  • Systemic chemotherapy has demonstrated minimal benefit for HCC patients.

Purpose of the Study:

  • To review recent immunotherapy trials for Hepatocellular Carcinoma (HCC).
  • To evaluate the safety and efficacy of immunotherapy in HCC treatment.

Main Methods:

  • Review of recent clinical trials investigating immunotherapy in HCC patients.
  • Analysis of safety data from enrolled participants.

Main Results:

  • Immunotherapy has been shown to be safe in patients with Hepatocellular Carcinoma (HCC).
  • Limited patient enrollment in most trials necessitates further investigation.

Conclusions:

  • Immunotherapy represents a safe therapeutic strategy for Hepatocellular Carcinoma (HCC).
  • Further research and larger trials are warranted to establish immunotherapy's efficacy in HCC treatment.