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Updated: Jul 5, 2026
06:56
Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
Published on: September 28, 2020
Laminin-332 and -511 in skin
Koji Sugawara1, Daisuke Tsuruta, Masamitsu Ishii
1Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Experimental Dermatology
|May 14, 2008
Summary
Extracellular matrix proteins, like skin laminins, regulate cell behavior and signaling. This review explores how laminins influence keratinocyte adhesion, migration, and skin development, impacting skin cancer.
Area of Science:
- Cell Biology
- Dermatology
- Biochemistry
Background:
- Extracellular matrix (ECM) proteins were traditionally viewed as structural supports.
- Emerging evidence highlights ECM's role in regulating cellular processes like growth, adhesion, division, movement, and apoptosis.
- ECM proteins mediate these functions via cell surface receptors, including integrins and syndecans.
Purpose of the Study:
- To review the roles of specific skin laminin isoforms (laminin-511 and laminin-332) in keratinocyte behavior.
- To elucidate the mechanisms of "outside-in" and "inside-out" signal transduction involving laminins and cell surface receptors.
- To discuss laminin involvement in skin appendage development and skin cancer pathogenesis.
Main Methods:
- Literature review focusing on laminin isoforms in skin.
- Analysis of "outside-in" signaling via laminin-receptor interactions.
- Examination of "inside-out" signaling regulating laminin matrix assembly by integrins.
Main Results:
- Laminins bind to membrane-penetrating receptors, influencing keratinocyte behavior.
- Integrins regulate the assembly of laminin-rich matrices.
- Laminin signaling dictates whether keratinocytes migrate or adhere stably.
Conclusions:
- Laminins are critical regulators of keratinocyte function, influencing adhesion and migration.
- Laminins play significant roles in skin appendage development.
- Dysregulation of laminin function contributes to skin cancer development.
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