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Effectiveness of an acellular pertussis vaccine in Japanese children during a non-epidemic period: a matched

K Okada1, Y Ohashi, F Matsuo

  • 1Division of Pediatrics, Fukuoka National Hospital, National Hospital Organization, Japan. okadak@mfukuoka2.hosp.go.jp

Epidemiology and Infection
|May 14, 2008
PubMed

Insights

Acellular pertussis vaccines (DTaP) significantly reduced pertussis cases in Japan. DTaP vaccination demonstrated high effectiveness, preventing severe coughing episodes during non-epidemic periods.

Area of Science:

  • Pediatrics
  • Immunology
  • Epidemiology

Background:

  • Pertussis (whooping cough) incidence declined in Japan post-DTaP vaccine introduction in 1981.
  • Systematic evaluation of DTaP vaccine effectiveness during non-epidemic periods was lacking.

Purpose of the Study:

  • To evaluate the vaccine effectiveness (VE) of the Kaketsuken DTaP vaccine.
  • To assess DTaP vaccine efficacy in Japanese children during a non-epidemic period.

Main Methods:

  • Matched case-control study design.
  • Utilized data from Basic Resident Registration and Maternal and Child Health Handbooks.
  • Included 15 pertussis cases and 59 controls, analyzing DTaP vaccination history.

Main Results:

  • VE of 3 or 4 DTaP vaccinations against pertussis was high.
  • Effectiveness was 96.9% for cough lasting 7 days, 96.4% for 14 days, and 95.9% for 21 days.

Conclusions:

  • DTaP vaccination demonstrated significant effectiveness in preventing pertussis.
  • Findings support the continued use of DTaP vaccines for pertussis control in Japan.

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