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Updated: Aug 30, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones
H A Albrecht1, G Beskid, J G Christenson
1Roche Research Center, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.
Abstract:
When cephalosporins exert their biological activity by reacting with bacterial enzymes, opening of the beta-lactam ring can lead to expulsion of the 3'-substituent. A series of cephalosporins was prepared in which antibacterial quinolones were linked to the 3'-position through a quaternary nitrogen. Like the 3'-ester-linked dual-action cephalosporins reported earlier, these compounds demonstrated a broad spectrum of antibacterial activity derived from cephalosporin-like and quinolone-like components, suggesting a dual mode of action.
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