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Related Experiment Video

Updated: Jul 5, 2026

Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet

Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet

Published on: January 3, 2017

Potentially adverse interactions between haloperidol and valerian.

C L Dalla Corte¹, R Fachinetto, D Colle

¹Universidade Federal de Santa Maria, Centro de Ciências Naturais e Exatas, Departamento de Química, Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Camobi, Cep 97105-900, Santa Maria, RS, Brazil.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association

|May 14, 2008

Summary

This study investigated haloperidol (HP) and valerian interactions, finding they may cause adverse liver effects. Concomitant use increased oxidative stress and inhibited delta-aminolevulinate dehydratase (delta-ALA-D) in the liver.

Related Experiment Videos

Last Updated: Jul 5, 2026

Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet

Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet

Published on: January 3, 2017

Area of Science:

Pharmacology
Toxicology
Biochemistry

Background:

Haloperidol (HP) is an antipsychotic, and valerian is a herbal supplement.
Investigating potential drug-herb interactions is crucial for patient safety.
Oxidative stress and liver/kidney function are key indicators of drug toxicity.

Purpose of the Study:

To evaluate the impact of haloperidol (HP), valerian, and their combination on liver and kidney functions in rats.
To assess the effects on oxidative stress markers and specific enzyme activities.

Main Methods:

Rats were treated with HP, valerian, or both.
Liver and kidney functions were assessed by measuring oxidative stress parameters, enzyme activities (delta-ALA-D, AST, ALT), and reactive species.
Glutathione (GSH) levels, lipid peroxidation, and dichlorofluorescein (DCFH) were quantified.

Main Results:

Valerian alone had no significant effect on oxidative stress.
HP alone caused GSH depletion in the liver.
Combined HP and valerian increased hepatic lipid peroxidation, DCFH production, and inhibited hepatic delta-ALA-D activity.
Serum ALT levels were elevated in rats treated with HP and with the HP-valerian combination.

Conclusions:

Concomitant administration of haloperidol and valerian may lead to adverse hepatic effects, including oxidative stress.
Hepatic delta-aminolevulinate dehydratase (delta-ALA-D) inhibition and elevated ALT suggest potential liver toxicity from the combination.
These findings highlight the importance of considering potential adverse interactions between antipsychotics and herbal supplements.