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Updated: Jul 5, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Published on: May 17, 2018

The relationship between fatigue and cardiac functioning.

Richard Nelesen1, Yasmin Dar, KaMala Thomas

  • 1Department of Psychiatry, University of California San Diego, La Jolla, CA 92093-0804, USA.

Archives of Internal Medicine
|May 14, 2008
PubMed
Summary

Fatigue is linked to reduced cardiac output and stroke index in healthy individuals, even at rest. This suggests underlying hemodynamic changes associated with subjective fatigue complaints.

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Area of Science:

  • Cardiovascular physiology
  • Psychoneuroimmunology
  • Human fatigue research

Background:

  • Commonly studied cardiac markers like heart rate (HR) and blood pressure (BP) lack depth in fatigue research.
  • Cardiac output (CO) and stroke volume (SV) offer a more comprehensive view of cardiac function in relation to fatigue.

Purpose of the Study:

  • To investigate the relationship between self-reported fatigue and hemodynamic parameters (CO, SV).
  • To assess hemodynamic responses to a public speaking stressor in individuals with varying fatigue levels.

Main Methods:

  • 142 healthy individuals were categorized into low, moderate, or high fatigue groups using the Profile of Moods State fatigue scale.
  • Impedance cardiography measured HR, SV, and CO at rest and during a public speaking stressor.
  • Stroke index (SI) and cardiac index (CI) were calculated; data analyzed using regression and ANOVA.

Main Results:

  • Fatigue correlated with decreased CI and SI at rest, independent of demographics and depression.
  • Both high-fatigue and low-fatigue groups showed lower CI and SI compared to moderate-fatigue groups, at rest and during stress.
  • HR and BP increased significantly during the stressor, as expected.

Conclusions:

  • Subjective fatigue complaints in healthy individuals are associated with measurable hemodynamic alterations.
  • Reduced cardiac output and stroke index may be physiological correlates of fatigue.