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Updated: Jul 5, 2026
Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection
Published on: July 16, 2019
Inhibitory effect of interferon-beta on mouse spleen-derived mast cells
1First Department of Internal Medicine School of Medicine Showa University Hatanodai, Shinagawa-ku Tokyo 142 Japan.
Abstract:
Preparations of murine recombinant interferon (Mu-rIFN)-alpha, -beta and -gamma were assessed for their influence on in vitro growth of mast cells from normal mouse spleen cells (Sp C). Mast cell growth was inhibited by Mu-rIFNs when Sp C were exposed throughout the entire culture period to Mu-rIFNs. The most potent inhibitor of mast cell growth was Mu-rIFN-gamma, followed by Mu-rIFN-beta; Mu-rlFN-alpha had little effect. When added to IC-2 cells, clonal mast cell progenitor, both Mu-rlFN-beta and -gamma), significantly inhibited proliferative response of the target cells. The suppressive effect of Mu-rIFNs on IC-2 cells was selectively abolished by monoclonal antibodies against Mu-rIFN-beta and -gamma.
