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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Inhibition of Immune Complex-Induced Inflammation by A small Molecular Weight Selectin Antagonist

X Nair1, G Todderud, L Davern

  • 1Bristol-Myers Squibb Pharmaceutical Research Institute 100 Forest Avenue Buffalo NY 14213 USA.

Mediators of Inflammation
|January 1, 1994
PubMed

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Selectins

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The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...