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Negative correlation between maorophage proooagulant and migraion ability in the course of inflammation

I Vilić1, L M Prokić

  • 1Institute of Physiology Medical Faculty Belgrade University PO Box 783 Belgrade 11001 Serbia.

Mediators of Inflammation
|January 1, 1996
PubMed

Insights

Macrophage procoagulant activity (PCA) may hinder cell movement. This study found that increased PCA in macrophages during inflammation correlated with decreased random migration, suggesting coagulation immobilizes these immune cells at inflammation sites.

Area of Science:

  • Immunology
  • Cell Biology
  • Hematology

Background:

  • Macrophage procoagulant activity (PCA) is implicated in cell migration.
  • The relationship between PCA and macrophage migration requires further investigation.

Purpose of the Study:

  • To investigate the relationship between macrophage procoagulant activity (PCA) and random migration ability.
  • To determine the in vivo induction and temporal changes of PCA in macrophages during inflammation.

Main Methods:

  • Assaying PCA and random migration in guinea-pig peritoneal resident macrophages.
  • Analyzing macrophages elicited by sterile inflammation induction over 6 days.

Main Results:

  • Demonstrated in vivo induction of PCA in macrophages during inflammation.
  • Observed a decline in PCA over time during the inflammatory process.
  • Established a clear negative correlation between PCA levels and random migration ability.

Conclusions:

  • Macrophage PCA is induced in vivo during inflammation.
  • Increased PCA correlates with reduced macrophage migration.
  • Local coagulation induced by macrophages may immobilize cells at inflammation sites.

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