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Naturally occurring hydroxy napthoquinones and their iron complexes as modulators of radiation induced lipid
A S Kumbhar1, S B Padhye, Jitender
1Department of Chemistry University of Pune Pune 4110 07 India.
Abstract:
The modulation of radiation induced lipid peroxidation in synaptosomes by iron (II) and iron (III) complexes of two naturally occurring and therapeutically relevant naphthoquinones viz. 5,hydroxy-1,4 naphthoquinone; juglone and 2,hydroxy-1,4 naphthoquinone; lawsone, have been studied. At lower concentrations the complexes enhance lipid peroxidation predominantly through redox cycling as observed for Fe(II)- juglonate while at higher concentrations the complexes tend to limit lipid peroxidation through fast recombinations.
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